Gene regulatory elements of the cardiac conduction system
نویسندگان
چکیده
منابع مشابه
Gene regulatory networks in cardiac conduction system development.
The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Given its critical role in coordinating cardiac performance, a detailed analysis of the molecular mechanisms underlying conduction system formation should inform our understanding of arrhythmia pathophysiology and affect the development of novel therapeutic strategies. His...
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The cardiac conduction system (CCS) initiates and coordinately propagates the electrical impulse to orchestrate the heartbeat. It consists of a set of interconnected components with shared properties. A better understanding of the origin and specification of CCS lineages has allowed us to better comprehend the etiology of CCS disease and has provided leads for development of therapies. A variet...
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The heterogeneous tissues of the cardiac pacemaking and conduction system are responsible for setting, maintaining and coordinating the rhythmic pumping of the heart (reviewed Thompson et al., 1995; Moorman et al., 1998; Gourdie et al., 1999). Anomalous development of this specialized network has been implicated in pediatric arrhythmia and other congenital abnormalities of cardiac activation (S...
متن کاملDevelopment of the cardiac conduction system.
The cardiac conduction system (CCS) is a specialized tissue network that initiates and maintains a rhythmic heartbeat. The CCS consists of several functional subcomponents responsible for producing a pacemaking impulse and distributing action potentials across the heart in a coordinated manner. The formation of the distinct subcomponents of the CCS occurs within a precise temporal and spatial f...
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ژورنال
عنوان ژورنال: Briefings in Functional Genomics
سال: 2013
ISSN: 2041-2649,2041-2657
DOI: 10.1093/bfgp/elt031